Publications

34. Shao, Q., Khawaja, A., Singh, V., Zhang, J., Adori, M., Innis, C.A., Castro Dopico, X., Rorbach, J. (2024). Structural Basis of T Cell Toxicity Induced by Tigecycline Binding to the Mitochondrial Ribosome. Research Square [Preprint].

33. Halte, M., Popp, P.F., Hathcock, D., Severn, J., Fischer, S., Goosmann, C., Ducret, A., Charpentier, E., Tu, Y., Lauga, E., Erhardt, M., Renault, T.T. (2024). Bacterial motility depends on a critical flagellum length and energy-optimised assembly. bioRxiv [Preprint].

32. Gillard, M. & Innis, C.A. (2024). iTP-Seq: a scalable profiling method to study context-dependent translational events in vitro. PROTOCOL (Version 1) available at Protocol Exchange.

31. Bhattacharya, A., Renault, T.T., Innis, C.A. (2024). The ribosome as a small-molecule sensor. Curr Opin Microbiol. 77, 102418.  

30. Fostier, C.R., Ousalem, F., Leroy, E.C., Ngo, S., Soufari, H., Innis, C.A., Hashem, Y., Boël, G.  (2023). Regulation of the macrolide resistance ABC-F translation factor MsrD. Nat Commun 14, 3891.  

29. Leroy, E.C., Perry, T.N., Renault, T.T., Innis, C.A. (2023). Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs. Nat Chem Biol 19, 1091-1096.  

News & Views by Vázquez-Laslop, N. & Polikanov, Y.S. (2023). Nat Chem Biol 19, 1044-1045

28. Manteca, A., Gadea, A., Van Assche, D., Cossard, P., Gillard-Bocquet, M., Beneyton, T., Innis, C.A., Baret, J.C. (2021). Directed Evolution in Drops: Molecular Aspects and Applications. ACS Synth Biol 10, 2772-2783.  

27. van der Stel, A.X., Gordon, E.R., Sengupta, A., Martínez, A.K., Klepacki, D., Perry, T.N., Herrero Del Valle, A., Vázquez-Laslop, N., Sachs, M.S., Cruz-Vera, L.R., Innis, C.A. (2021). Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling. Nat Commun 12, 5340.  

26. Beckert, B., Leroy, E.C., Sothiselvam, S., Bock, L.V., Svetlov, M.S., Graf, M., Arenz, S., Abdelshahid, M., Seip, B., Grubmüller, H., Mankin, A.S., Innis, C.A., Vázquez-Laslop, N., Wilson, D.N. (2021) Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics. Nat Commun 12, 4466.  

25. Herrero Del Valle, A. & Innis, C.A. (2020). Prospects for antimicrobial development in the cryo-EM era – a focus on the ribosome. FEMS Microbiol Rev. 44, 793-803.  

24. Cytryńska, M., Rahnamaeian, M., Zdybicka-Barabas, A., Dobslaff, K., Züchner, T., Sacheau, G., Innis, C.A., Vilcinskas, A. (2020). Proline-Rich Antimicrobial Peptides in Medicinal Maggots of Lucilia sericata Interact With Bacterial DnaK But Do Not Inhibit Protein Synthesis. Front Pharmacol. 11, 532.  

23. Herrero del Valle, A., Seip, B., Cervera-Marzal, I., Sacheau, G., Seefeldt, A.C., Innis, C.A. (2020). Ornithine capture by a translating ribosome controls bacterial polyamine synthesis. Nat Microbiol  5, 554–561.  

22. Charon, J., Manteca, A., Innis, C.A. (2019). Using the bacterial ribosome as a discovery platform for peptide-based antibiotics. Biochemistry 58, 75-84.

Editorial by Schepartz, A. (2019). Biochemistry 58, 1-6

21. Seip, B., Sacheau, G., Dupuy, D., Innis, C.A. (2018). Ribosomal stalling landscapes revealed by high-throughput inverse toeprinting of mRNA libraries. Life Science Alliance 1 (5).  

20. Mardirossian, M., Pérébaskine, N., Benincasa, M., Gambato, S., Hofmann, S., Huter, P., Müller, C., Hilpert, K., Innis, C.A., Tossi, A., Wilson, D.N. (2018). The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome. Cell Chem Biol. 25, 530-539.

19. Graf, M., Mardirossian, M., Nguyen, F., Seefeldt, A.C., Guichard, G., Scocchi, M., Innis, C.A., Wilson, D.N. (2017). Proline-rich antimicrobial peptides targeting protein synthesis. Nat Prod Rep. 34, 702-711.

18. Arenz, S., Bock, L.V., Graf, M., Innis, C.A., Beckmann, R., Grubmüller, H., Vaiana, A.C., Wilson, D.N. (2016). A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest. Nat Commun. 7, 12026.

17. Seip, B. & Innis, C.A. (2016). How widespread is metabolite sensing by ribosome-arresting nascent peptides? J Mol Biol. 428, 2217-2227.

16. Seefeldt, A.C., Graf, M., Nguyen, F., Pérébaskine, N., Arenz, S., Mardirossian, M., Scocchi, M., Wilson, D.N., Innis, C.A. (2016). Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome. Nucleic Acids Res. 44, 2429-2438.    

15. Wilson, D.N., Guichard, G., Innis, C.A. (2015). Antimicrobial peptides target ribosomes. Oncotarget 6, 16826-16827.    

14. Seefeldt, A.C., Nguyen, F., Antunes, S., Pérébaskine, N., Graf, M., Arenz, S., Inampudi, K.K., Douat, C., Guichard, G., Wilson, D.N., Innis, C.A. (2015). The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex. Nat Struct Mol Biol 22, 470-475.  

Comment in This Week in Microbiology (TWiM) podcast #105 (June 5, 2015). Listen to the podcast.

13. Sohmen, D., Chiba, S., Shimokawa-Chiba, N., Innis, C.A., Berninghausen, O., Beckmann, R., Ito, K., Wilson, D.N. (2015). Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling. Nat Commun 6, 6941.  

12. Polikanov, Y.S., Steitz, T.A., Innis, C.A. (2014). A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosone. Nat Struct Mol Biol 21, 787-793.   

11. Steitz, T.A., Blaha, G., Innis, C.A., Stanley, R.E., Bulkley, D. (2012). Structural Studies of the Functional Complexes of the 50S and 70S Ribosome, a Major Antibiotic Target. Macromolecular Crystallography, 135-148.  

10. Innis, C.A., Blaha, G., Bulkley, D., Steitz, T.A. (2011) Structural studies of complexes of the 70S ribosome. Ribosomes, 31-43.  

9. Bulkley, D., Innis, C.A., Blaha, G., Steitz, T.A. (2010). Revisiting the structures of several antibiotics bound to the eubacterial ribosome. PNAS 107, 17158-63.   

Comment by Douthwaite (2010). Designer drugs for discerning bugs. PNAS 107, 17065-6.  

8. Seidelt, B., Innis, C.A., Wilson, D.N., Gartmann, M., Armache, J.P., Villa, E., Trabuco, L.G., Becker, T., Mielke, T., Schulten, K., Steitz, T.A., Beckmann, R. (2009). Structural insight into nascent chain-mediated translational stalling. Science 326, 1412-1415. 

Comment by Kampmann & Blobel (2009). Nascent proteins caught in the act. Science 326, 1352-1353.  

7. Ying, F.F., Bailey, S., Innis, C.A., Ciubotaru, M., Kamtekar, S., Steitz, T.A., Schatz, D.G. (2009). Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol 16, 499-508.   

6. Innis, C.A. (2007). siteFiNDER|3D: a web-based tool for predicting the location of functional sites in proteins. Nucleic Acids Res 35, W489-494.  

5. Innis, C.A., Anand, A.P., Sowdhamini, R. (2004). Prediction of functional sites in proteins using Conserved Functional Group analysis. J Mol Biol 337, 1053-1068.  

4. Innis, C.A., Hyvönen, M. (2003). Crystal structures of the heparan sulphate-binding domain of follistatin: insights into ligand binding. J Biol Chem 278, 39969-39977.   

3. Williams, M.G., Shirai, H., Shi, J., Nagendra, H.G., Mueller, J., Mizuguchi, K., Miguel, R.N., Lovell, S.C., Innis, C.A., Deane, C.M., Chen, L., Campillo, N., Burke, D.F., Blundell, T.L., de Bakker, P.I. (2001). Sequence-structure homology recognition by iterative alignment refinement and comparative modeling. Proteins Suppl 5, 92-7.  

2. Innis, C.A., Shi, J., Blundell, T.L. (2000). Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis. Protein Eng 13, 839-847.  

1. Blundell, T.L., Burke, D.F., Chirgadze, D., Dhanaraj, V., Hyvönen, M., Innis, C.A., Parisini, E., Pellegrini, L., Sayed, M., Sibanda, B.L. (2000). Protein-protein interactions in receptor activation and intracellular signalling. Biol Chem 381, 955-959.