Publications

2019

23. Herrero del Valle, A., Seip, B., Cervera-Marzal, I., Sacheau, G., Seefeldt, A.C., Innis, C.A. (2019). Ornithine capture by a translating ribosome controls bacterial polyamine synthesis. bioRχiv,

 

22. Charon, J., Manteca, A., Innis, C.A. (2019). Using the bacterial ribosome as a discovery platform for peptide-based antibiotics. Biochemistry 58, 75-84. pubmed

2018

21. Seip, B., Sacheau, G., Dupuy, D., Innis, C.A. Life Science Alliance 1 (5). Related image

 

20. Mardirossian, M., Pérébaskine, N., Benincasa, M., Gambato, S., Hofmann, S., Huter, P., Müller, C., Hilpert, K., Innis, C.A., Tossi, A., Wilson, D.N. Cell Chem Biol. 25, 530-539. pubmed

2017

19. Nat Prod Rep. 34, 702-711. pubmed

2016

18. Arenz, S., Bock, L.V., Graf, M., Innis, C.A., Beckmann, R., Grubmüller, H., Vaiana, A.C., Wilson, D.N. (2016). A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest. Nat Commun. 7, 12026. pdf pubmed

 

17. Seip, B. & Innis, C.A. (2016). How widespread is metabolite sensing by ribosome-arresting nascent peptides? J Mol Biol. 428, 2217-2227. pdf pubmed

 

16. Seefeldt, A.C., Graf, M., Nguyen, F., Pérébaskine, N., Arenz, S., Mardirossian, M., Scocchi, M., Wilson, D.N., Innis, C.A. (2016). Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome. Nucleic Acids Res. 44, 2429-2438.  pdf  pubmed

2015

15. Wilson, D.N., Guichard, G., Innis, C.A. (2015). Antimicrobial peptides target ribosomes. Oncotarget 6, 16826-16827.  pdf  pubmed

 

14. Seefeldt, A.C., Nguyen, F., Antunes, S., Pérébaskine, N., Graf, M., Arenz, S., Inampudi, K.K., Douat, C., Guichard, G., Wilson, D.N., Innis, C.A. (2015). The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex. Nat Struct Mol Biol 22, 470-475.  pubmed

 

Comment in This Week in Microbiology (TWiM) podcast #105 (June 5, 2015). Listen to the podcast.

 

13. Sohmen, D., Chiba, S., Shimokawa-Chiba, N., Innis, C.A., Berninghausen, O., Beckmann, R., Ito, K., Wilson, D.N. (2015). Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling. Nat Commun 6, 6941.pdf  pubmed

2014

12. Polikanov, Y.S., Steitz, T.A., Innis, C.A. (2014). A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosone. Nat Struct Mol Biol 21, 787-793. pdf  pubmed

Pre-2013

11. Steitz, T.A., Blaha, G., Innis, C.A., Stanley, R.E., Bulkley, D. (2012). Structural Studies of the Functional Complexes of the 50S and 70S Ribosome, a Major Antibiotic Target. Macromolecular Crystallography, 135-148.  pubmed

 

10. Innis, C.A., Blaha, G., Bulkley, D., Steitz, T.A. (2011) Structural studies of complexes of the 70S ribosome. Ribosomes, 31-43.  pubmed

 

9. Bulkley, D., Innis, C.A., Blaha, G., Steitz, T.A. (2010). Revisiting the structures of several antibiotics bound to the eubacterial ribosome. PNAS 107, 17158-63.   pubmed

 

Comment by Douthwaite (2010). Designer drugs for discerning bugs. PNAS 107, 17065-6.  pubmed

 

8. Seidelt, B., Innis, C.A., Wilson, D.N., Gartmann, M., Armache, J.P., Villa, E., Trabuco, L.G., Becker, T., Mielke, T., Schulten, K., Steitz, T.A., Beckmann, R. (2009). Structural insight into nascent chain-mediated translational stalling. Science 326, 1412-1415. pubmed

 

Comment by Kampmann & Blobel (2009). Nascent proteins caught in the act. Science 326, 1352-1353.  pubmed

 

7. Ying, F.F., Bailey, S., Innis, C.A., Ciubotaru, M., Kamtekar, S., Steitz, T.A., Schatz, D.G. (2009). Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol 16, 499-508.   pubmed

 

6. Innis, C.A. (2007). siteFiNDER|3D: a web-based tool for predicting the location of functional sites in proteins. Nucleic Acids Res 35, W489-494.  pubmed

 

5. Innis, C.A., Anand, A.P., Sowdhamini, R. (2004). Prediction of functional sites in proteins using Conserved Functional Group analysis. J Mol Biol 337, 1053-1068.  pubmed

 

4. Innis, C.A., Hyvönen, M. (2003). Crystal structures of the heparan sulphate-binding domain of follistatin: insights into ligand binding. J Biol Chem 278, 39969-39977.   pubmed

 

3. Williams, M.G., Shirai, H., Shi, J., Nagendra, H.G., Mueller, J., Mizuguchi, K., Miguel, R.N., Lovell, S.C., Innis, C.A., Deane, C.M., Chen, L., Campillo, N., Burke, D.F., Blundell, T.L., de Bakker, P.I. (2001). Sequence-structure homology recognition by iterative alignment refinement and comparative modeling. Proteins Suppl 5, 92-7.  pubmed

 

2. Innis, C.A., Shi, J., Blundell, T.L. (2000). Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis. Protein Eng 13, 839-847.  pubmed

 

1. Blundell, T.L., Burke, D.F., Chirgadze, D., Dhanaraj, V., Hyvönen, M., Innis, C.A., Parisini, E., Pellegrini, L., Sayed, M., Sibanda, B.L. (2000). Protein-protein interactions in receptor activation and intracellular signalling. Biol Chem 381, 955-959.  pubmed