Publications

23. Herrero del Valle, A., Seip, B., Cervera-Marzal, I., Sacheau, G., Seefeldt, A.C., Innis, C.A. (2019). Ornithine capture by a translating ribosome controls bacterial polyamine synthesis. bioRχiv, doi: https://doi.org/10.1101/604074.

22. Charon, J., Manteca, A., Innis, C.A. (2019). Using the bacterial ribosome as a discovery platform for peptide-based antibiotics. Biochemistry 58, 75-84.

21. Seip, B., Sacheau, G., Dupuy, D., Innis, C.A. (2018). Ribosomal stalling landscapes revealed by high-throughput inverse toeprinting of mRNA libraries. Life Science Alliance 1 (5).

20. Mardirossian, M., Pérébaskine, N., Benincasa, M., Gambato, S., Hofmann, S., Huter, P., Müller, C., Hilpert, K., Innis, C.A., Tossi, A., Wilson, D.N. (2018). The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome. Cell Chem Biol. 25, 530-539.

19. Graf, M., Mardirossian, M., Nguyen, F., Seefeldt, A.C., Guichard, G., Scocchi, M., Innis, C.A., Wilson, D.N. (2017). Proline-rich antimicrobial peptides targeting protein synthesis. Nat Prod Rep. 34, 702-711.

18. Arenz, S., Bock, L.V., Graf, M., Innis, C.A., Beckmann, R., Grubmüller, H., Vaiana, A.C., Wilson, D.N. (2016). A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest. Nat Commun. 7, 12026.

17. Seip, B. & Innis, C.A. (2016). How widespread is metabolite sensing by ribosome-arresting nascent peptides? J Mol Biol. 428, 2217-2227.

16. Seefeldt, A.C., Graf, M., Nguyen, F., Pérébaskine, N., Arenz, S., Mardirossian, M., Scocchi, M., Wilson, D.N., Innis, C.A. (2016). Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome. Nucleic Acids Res. 44, 2429-2438.    

15. Wilson, D.N., Guichard, G., Innis, C.A. (2015). Antimicrobial peptides target ribosomes. Oncotarget 6, 16826-16827.    

14. Seefeldt, A.C., Nguyen, F., Antunes, S., Pérébaskine, N., Graf, M., Arenz, S., Inampudi, K.K., Douat, C., Guichard, G., Wilson, D.N., Innis, C.A. (2015). The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex. Nat Struct Mol Biol 22, 470-475.  

Comment in This Week in Microbiology (TWiM) podcast #105 (June 5, 2015). Listen to the podcast.

13. Sohmen, D., Chiba, S., Shimokawa-Chiba, N., Innis, C.A., Berninghausen, O., Beckmann, R., Ito, K., Wilson, D.N. (2015). Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling. Nat Commun 6, 6941.  

12. Polikanov, Y.S., Steitz, T.A., Innis, C.A. (2014). A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosone. Nat Struct Mol Biol 21, 787-793.   

11. Steitz, T.A., Blaha, G., Innis, C.A., Stanley, R.E., Bulkley, D. (2012). Structural Studies of the Functional Complexes of the 50S and 70S Ribosome, a Major Antibiotic Target. Macromolecular Crystallography, 135-148.  

10. Innis, C.A., Blaha, G., Bulkley, D., Steitz, T.A. (2011) Structural studies of complexes of the 70S ribosome. Ribosomes, 31-43.  

9. Bulkley, D., Innis, C.A., Blaha, G., Steitz, T.A. (2010). Revisiting the structures of several antibiotics bound to the eubacterial ribosome. PNAS 107, 17158-63.   

Comment by Douthwaite (2010). Designer drugs for discerning bugs. PNAS 107, 17065-6.  

8. Seidelt, B., Innis, C.A., Wilson, D.N., Gartmann, M., Armache, J.P., Villa, E., Trabuco, L.G., Becker, T., Mielke, T., Schulten, K., Steitz, T.A., Beckmann, R. (2009). Structural insight into nascent chain-mediated translational stalling. Science 326, 1412-1415. 

Comment by Kampmann & Blobel (2009). Nascent proteins caught in the act. Science 326, 1352-1353.  

7. Ying, F.F., Bailey, S., Innis, C.A., Ciubotaru, M., Kamtekar, S., Steitz, T.A., Schatz, D.G. (2009). Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol 16, 499-508.   

6. Innis, C.A. (2007). siteFiNDER|3D: a web-based tool for predicting the location of functional sites in proteins. Nucleic Acids Res 35, W489-494.  

5. Innis, C.A., Anand, A.P., Sowdhamini, R. (2004). Prediction of functional sites in proteins using Conserved Functional Group analysis. J Mol Biol 337, 1053-1068.  

4. Innis, C.A., Hyvönen, M. (2003). Crystal structures of the heparan sulphate-binding domain of follistatin: insights into ligand binding. J Biol Chem 278, 39969-39977.   

3. Williams, M.G., Shirai, H., Shi, J., Nagendra, H.G., Mueller, J., Mizuguchi, K., Miguel, R.N., Lovell, S.C., Innis, C.A., Deane, C.M., Chen, L., Campillo, N., Burke, D.F., Blundell, T.L., de Bakker, P.I. (2001). Sequence-structure homology recognition by iterative alignment refinement and comparative modeling. Proteins Suppl 5, 92-7.  

2. Innis, C.A., Shi, J., Blundell, T.L. (2000). Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis. Protein Eng 13, 839-847.  

1. Blundell, T.L., Burke, D.F., Chirgadze, D., Dhanaraj, V., Hyvönen, M., Innis, C.A., Parisini, E., Pellegrini, L., Sayed, M., Sibanda, B.L. (2000). Protein-protein interactions in receptor activation and intracellular signalling. Biol Chem 381, 955-959.