Publications

2023

30. Fostier, C.R., Ousalem, F., Leroy, E.C., Ngo, S., Soufari, H., Innis, C.A., Hashem, Y., Boël, G.  (2023). Regulation of the macrolide resistance ABC-F translation factor MsrD. Nat Commun 14, 3891. pdf pubmed

 

29. Leroy, E.C., Perry, T.N., Renault, T.T., Innis, C.A. (2023). Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs. Nat Chem Biol 19, 1091-1096. https://www.biorxiv.org/sites/default/files/site_logo/bioRxiv_logo_homepage.png  pubmed

 

News & Views by Vázquez-Laslop, N. & Polikanov, Y.S. (2023). Nat Chem Biol 19, 1044-1045 pubmed

2021

28. Manteca, A., Gadea, A., Van Assche, D., Cossard, P., Gillard-Bocquet, M., Beneyton, T., Innis, C.A., Baret, J.C. (2021). Directed Evolution in Drops: Molecular Aspects and Applications. ACS Synth Biol 10, 2772-2783. pdf pubmed

 

27. van der Stel, A.X., Gordon, E.R., Sengupta, A., Martínez, A.K., Klepacki, D., Perry, T.N., Herrero Del Valle, A., Vázquez-Laslop, N., Sachs, M.S., Cruz-Vera, L.R., Innis, C.A. (2021). Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling. Nat Commun 12, 5340. pdf pubmed

 

26. Beckert, B., Leroy, E.C., Sothiselvam, S., Bock, L.V., Svetlov, M.S., Graf, M., Arenz, S., Abdelshahid, M., Seip, B., Grubmüller, H., Mankin, A.S., Innis, C.A., Vázquez-Laslop, N., Wilson, D.N. (2021) Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics. Nat Commun 12, 4466. pdf pubmed

2020

25. Herrero Del Valle, A. & Innis, C.A. (2020). Prospects for antimicrobial development in the cryo-EM era – a focus on the ribosome. FEMS Microbiol Rev. 44, 793-803. pdf pubmed

 

24. Cytryńska, M., Rahnamaeian, M., Zdybicka-Barabas, A., Dobslaff, K., Züchner, T., Sacheau, G., Innis, C.A., Vilcinskas, A. (2020). Proline-Rich Antimicrobial Peptides in Medicinal Maggots of Lucilia sericata Interact With Bacterial DnaK But Do Not Inhibit Protein Synthesis. Front Pharmacol. 11, 532. pdf pubmed

 

23. Herrero del Valle, A., Seip, B., Cervera-Marzal, I., Sacheau, G., Seefeldt, A.C., Innis, C.A. (2020). Ornithine capture by a translating ribosome controls bacterial polyamine synthesis. Nat Microbiol 

2019

22. Charon, J., Manteca, A., Innis, C.A. (2019). Using the bacterial ribosome as a discovery platform for peptide-based antibiotics. Biochemistry 58, 75-84. pubmed

Editorial by Schepartz, A. (2019). Biochemistry 58, 1-6

2018

21. Seip, B., Sacheau, G., Dupuy, D., Innis, C.A. Life Science Alliance 1 (5). pdf pubmed

 

20. Mardirossian, M., Pérébaskine, N., Benincasa, M., Gambato, S., Hofmann, S., Huter, P., Müller, C., Hilpert, K., Innis, C.A., Tossi, A., Wilson, D.N. Cell Chem Biol. 25, 530-539. pdf pubmed

2017

19. Nat Prod Rep. 34, 702-711. pubmed

2016

18. Arenz, S., Bock, L.V., Graf, M., Innis, C.A., Beckmann, R., Grubmüller, H., Vaiana, A.C., Wilson, D.N. (2016). A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest. Nat Commun. 7, 12026. pdf pubmed

 

17. Seip, B. & Innis, C.A. (2016). How widespread is metabolite sensing by ribosome-arresting nascent peptides? J Mol Biol. 428, 2217-2227. pdf pubmed

 

16. Seefeldt, A.C., Graf, M., Nguyen, F., Pérébaskine, N., Arenz, S., Mardirossian, M., Scocchi, M., Wilson, D.N., Innis, C.A. (2016). Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome. Nucleic Acids Res. 44, 2429-2438.  pdf  pubmed

2015

15. Wilson, D.N., Guichard, G., Innis, C.A. (2015). Antimicrobial peptides target ribosomes. Oncotarget 6, 16826-16827.  pdf  pubmed

 

14. Seefeldt, A.C., Nguyen, F., Antunes, S., Pérébaskine, N., Graf, M., Arenz, S., Inampudi, K.K., Douat, C., Guichard, G., Wilson, D.N., Innis, C.A. (2015). The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex. Nat Struct Mol Biol 22, 470-475.  pubmed

 

Comment in This Week in Microbiology (TWiM) podcast #105 (June 5, 2015). Listen to the podcast.

 

13. Sohmen, D., Chiba, S., Shimokawa-Chiba, N., Innis, C.A., Berninghausen, O., Beckmann, R., Ito, K., Wilson, D.N. (2015). Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling. Nat Commun 6, 6941.pdf  pubmed

2014

12. Polikanov, Y.S., Steitz, T.A., Innis, C.A. (2014). A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosone. Nat Struct Mol Biol 21, 787-793. pdf  pubmed

Pre-2013

11. Steitz, T.A., Blaha, G., Innis, C.A., Stanley, R.E., Bulkley, D. (2012). Structural Studies of the Functional Complexes of the 50S and 70S Ribosome, a Major Antibiotic Target. Macromolecular Crystallography, 135-148.  pubmed

 

10. Innis, C.A., Blaha, G., Bulkley, D., Steitz, T.A. (2011) Structural studies of complexes of the 70S ribosome. Ribosomes, 31-43.  pubmed

 

9. Bulkley, D., Innis, C.A., Blaha, G., Steitz, T.A. (2010). Revisiting the structures of several antibiotics bound to the eubacterial ribosome. PNAS 107, 17158-63.   pubmed

 

Comment by Douthwaite (2010). Designer drugs for discerning bugs. PNAS 107, 17065-6.  pubmed

 

8. Seidelt, B., Innis, C.A., Wilson, D.N., Gartmann, M., Armache, J.P., Villa, E., Trabuco, L.G., Becker, T., Mielke, T., Schulten, K., Steitz, T.A., Beckmann, R. (2009). Structural insight into nascent chain-mediated translational stalling. Science 326, 1412-1415. pubmed

 

Comment by Kampmann & Blobel (2009). Nascent proteins caught in the act. Science 326, 1352-1353.  pubmed

 

7. Ying, F.F., Bailey, S., Innis, C.A., Ciubotaru, M., Kamtekar, S., Steitz, T.A., Schatz, D.G. (2009). Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis. Nat Struct Mol Biol 16, 499-508.   pubmed

 

6. Innis, C.A. (2007). siteFiNDER|3D: a web-based tool for predicting the location of functional sites in proteins. Nucleic Acids Res 35, W489-494.  pubmed

 

5. Innis, C.A., Anand, A.P., Sowdhamini, R. (2004). Prediction of functional sites in proteins using Conserved Functional Group analysis. J Mol Biol 337, 1053-1068.  pubmed

 

4. Innis, C.A., Hyvönen, M. (2003). Crystal structures of the heparan sulphate-binding domain of follistatin: insights into ligand binding. J Biol Chem 278, 39969-39977.   pubmed

 

3. Williams, M.G., Shirai, H., Shi, J., Nagendra, H.G., Mueller, J., Mizuguchi, K., Miguel, R.N., Lovell, S.C., Innis, C.A., Deane, C.M., Chen, L., Campillo, N., Burke, D.F., Blundell, T.L., de Bakker, P.I. (2001). Sequence-structure homology recognition by iterative alignment refinement and comparative modeling. Proteins Suppl 5, 92-7.  pubmed

 

2. Innis, C.A., Shi, J., Blundell, T.L. (2000). Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis. Protein Eng 13, 839-847.  pubmed

 

1. Blundell, T.L., Burke, D.F., Chirgadze, D., Dhanaraj, V., Hyvönen, M., Innis, C.A., Parisini, E., Pellegrini, L., Sayed, M., Sibanda, B.L. (2000). Protein-protein interactions in receptor activation and intracellular signalling. Biol Chem 381, 955-959.  pubmed